The main campus of UW-Platteville is located in the southwest quadrant of the city of Platteville.

Spanning over 330 acres, the main campus includes over 30 buildings in a park-like setting. Over the last decade, there has been extensive facility development on the campus. New buildings since 1997 include the Children’s Center, the Markee Pioneer Student Center, the greenhouse and adjacent gardens, Southwest Hall, Roundtree Commons and Engineering Hall.

Additionally, there have been major renovations to Doudna Hall, Russell Hall, Pioneer Tower, Ullrich Hall, the Art Building, Ullsvik Hall and Glenview Commons. There have also been extensive improvements in athletic and recreational facilities, including Ralph E. Davis Pioneer Stadium, the outdoor track and field facility, and the softball and baseball fields. A significant feature of the university campus is the Center for the Arts. The 565-seat concert hall is known for its excellent acoustics. There is also a 200-flexible seat theater and rehearsal halls in the facility. The center is home to the award-winning Performing Arts Series and productions from the Department of Performing and Visual Arts. 

Pioneer Farm, located about five miles southeast of the city of Platteville, is the university’s 450-acre systems research and education facility. Pioneer Farm features newly constructed buildings, including the Agriculture Technology Center, the Cooper Living and Learning Center, the Swine Center and the Dairy Center. The farm enterprise includes dairy, swine and beef herds plus corn, soybean and alfalfa cropping. Pioneer Farm is a key component of the Wisconsin Agricultural Stewardship Initiative, a statewide collaboration between producers, state government and the UW System to evaluate best management practices in Wisconsin and form policies based on practices that will enhance the environment and produce a profit for the producer. Pioneer Farm has developed to provide agricultural and environmental research in a production setting representative of Southwest Wisconsin and the Upper Mississippi Basin loess hills.

UW-Platteville also has facilities which can transmit or receive full motion or compressed video to or from anywhere in the world. Two distance education classrooms in Ottensman and Engineering Halls, are used primarily by the College of Engineering, Mathematics and Science, and third is used within Pioneer Tower by the College of Business, Industry, Life Science and Agriculture. A fourth facility is at the Pioneer Farm.